If you're replacing the dash harness, make sure you have the right one for your car, there are quite a few variations. With regards removing & replacing, it's not a bad job if you're methodical. Remove the instrument cluster, glove boxes & centre console, that should be enough stuff removed to let you do it.
If you're replacing the body harness, remove the rear seats & to make life easier, the drivers seat, then lift out the carpet & peel back the sill carpet.