Wider transmission tunnel (unless donor was an auto). Very different inner wings, chassis rails front cross member. If a Series I car you can add a different bonnet too.How much of a project do you want?
As others have said, there's no reason that it can't be done but it's far from just changing the engine: in addition to the main things already mentioned you can add different rate springs/dampers, front suspension changes, wider wheels, different front hubs, front valance, most of the exhaust etc. etc..
That sounds fun. Or go @sowen route and fit a turbocharged Saab 9000 engine, those can be safely tuned to 350+BHP (Although you'll want to fit a Jag diff to cope with the extra torque.You could supercharge your TC engine with and intercooled Mercedes unit...much cheaper and just as fast as a V8...